AUTHORS: Shaul Druckmann, Linqing Feng, Bokyoung Lee, Chaehyun Yook, Ting Zhao, Jeffrey C. Magee, Janelia Farm Research and Jinhyun Kim
ABSTRACT: The organization of synaptic connectivity within a neuronal circuit is a prime determinant of circuit function. We performed a comprehensive ﬁne-scale circuit mapping of hippocampal regions (CA3-CA1) using the newly developed synapse labeling method, mGRASP. This mapping revealed spatially nonuniform and clustered synaptic connectivity patterns. Furthermore, synaptic clustering was enhanced between groups of neurons that shared a similar developmental/migration time window, suggesting a mechanism for establishing the spatial structure of synaptic connectivity. Such connectivity patterns are thought to effectively engage active dendritic processing and storage mechanisms, thereby potentially enhancing neuronal feature selectivity.